What are risk factors for the development of calciphylaxis?

Updated: Feb 24, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
  • Print

The patient's history may reveal an event that is a suspected trigger or risk factor for the development of calciphylaxis. These triggers include the following [6, 9, 8, 21, 18, 19, 20, 24, 34, 35] :

  • Long-term obesity

  • Recent and sudden weight loss

  • Malnutrition

  • Infusion of medications such as iron dextran

  • Remote and/or recent use of immunosuppressive agents, especially corticosteroids

  • Liver disease

  • Connective-tissue disease

  • Diabetes mellitus and insulin injections

  • Use of vitamin D and calcium-based phosphate binders

  • Elevated aluminum levels

  • Concomitant vascular disease

  • Systemic hypercoagulability

  • Vitamin K deficiency

  • Concurrent use of warfarin anticoagulation: Current data suggest that warfarin therapy may lower protein C concentrations, leading to a procoagulant condition in the calcified vessel. Warfarin may also inhibit carboxylation of matrix Gla protein, an important inhibitor of calcification, thus promoting calcification

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!