What is the prognosis of calciphylaxis?

Updated: Feb 24, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

The prognosis is generally not good, with a mortality rate as high as 60-80% in patients with ulcerative disease. [9] The mortality rate is higher in patients with proximal disease than in those with only distal or acral disease. Patients who do not die of sepsis or organ failure frequently undergo amputation of an involved limb. Vascular calcification is theoretically reversible with aggressive management, but many patients have numerous comorbid diseases and intervention may be too late. [9] Currently, the 1- and 5-year survival rates are estimated to be 45% and 35%, respectively. A multidisciplinary approach with wound debridement, possible parathyroidectomy, and aggressive medical management may improve survival. [6] The impact of sodium thiosulfate on overall survival rate is yet to be determined. [33]


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