What is the prevalence of cutaneous malignancies following renal transplantation?

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Answer

Malignancies are more common after organ transplantation, and most are primary cutaneous malignancies. Incidence of nonmelanoma skin cancer is 20-40 times greater in renal transplant recipients (RTRs) than in the general population. This incidence increases as the time elapsed after transplantation increases because of the duration of immunosuppressive therapy. The cumulative risk of cutaneous malignancy is 10-30% at 5 years, 10-44% at 10 years, and 30-40% at 20 years. The prevalence of skin cancer varies according to geographic location, amount of ultraviolet (UV) light exposure, and predominant skin type. Most malignancies occur on sun-exposed areas and usually are found on the head, neck, and upper extremities. Multiple malignancies are a common occurrence.


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