Which dermatologic disorders are associated with renal transplantation?

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Although many lives are saved and maintained by dialytic intervention, most individuals endure a great deal of morbidity as a result of the inadequacy of renal replacement therapy. The best therapeutic option for many patients with end-stage renal disease (ESRD) is renal allograft transplantation. Successful transplantation results in regression of many of the metabolic and cutaneous changes of uremia. The 2007 US Renal Data System (USRDS) report revealed that over 18,000 individuals were transplanted in 2006, raising the number of renal transplant recipients in the United States to over 140,000. Unfortunately, renal transplantation has its own set of complications, primarily resulting from the immunosuppressive medications that are essential for allograft survival.

Studies have shown that 50-100% of renal transplant recipients (RTRs) have a transplant-related cutaneous complaint. Dermatologic disorders associated with renal transplantation are a function of the immunosuppressive medications prescribed, as well as the immunosuppressed condition produced. Factors such as time after transplantation, geographic location, climate, and skin type greatly modify the clinical disorders associated with renal transplantation.


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