What is the prevalence of xerosis in end-stage renal disease (ESRD)?

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Answer

Significant xerosis occurs for unknown reasons in 50-92% of the dialysis population. Some patients may develop acquired ichthyosis. Some authors have suggested that end-stage renal disease (ESRD)–associated xerosis may be a result of a decrease in water content in the epidermis. Clinical and histologic evaluations have shown an overall decrease in sweat volume in patients with uremia, as well as atrophy of sebaceous glands. These changes can allow dehydration of the stratum corneum; however, when directly measured, the water content of the epidermis in patients with ESRD has not been shown to be decreased.


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