How is polyarteritis nodosa associated with end-stage renal disease (ESRD)?

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Diseases that fall under the classification of polyarteritis/periarteritis nodosa (PAN) probably represent a group of distinct disorders with common cutaneous manifestations. These disorders may be subclassified as either systemic PAN or solely cutaneous PAN. Cutaneous lesions are reported to occur in 25-50% of patients with systemic PAN and include livedo reticularis and ulceration due to a necrotizing vasculitis and subcutaneous nodules caused by aneurysms of superficial vessels.

Renal involvement occurs in 25-60% of patients with systemic PAN and is a poor prognostic indicator. Historically, up to 50% of cases of systemic PAN were associated with hepatitis B (HBV) infection; data suggest the rate has fallen to closer to 15%. [11] Alternatively, as many as 14% of cases with cutaneous PAN have been associated with hepatitis C (HCV) infection. [12, 13]

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