How is lupus erythematosus associated with end-stage renal disease (ESRD)?

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Lupus erythematosus may be classified into 3 subsets including:

  • Chronic cutaneous lupus erythematosus (CCLE)

  • Subacute cutaneous lupus erythematosus (SCLE)

  • Systemic lupus erythematosus (SLE)

CCLE may be a devastating and disfiguring cutaneous disease, but significant systemic involvement occurs in less than 5-10% of patients. A higher percentage of patients with SCLE have systemic involvement, but severe renal disease is uncommon. [6] Mucocutaneous abnormalities occur in 85% of patients with SLE and may involve the skin, hair, or mucous membranes. [7] Renal disease occurs in 50-100% of patients with SLE and ranges from mildly abnormal findings in urinalysis to rapidly progressive and fulminant renal failure. Anti–double-stranded DNA (dsDNA) is a laboratory marker for patients with SLE at increased risk of developing renal disease. In contrast, patients with SCLE without renal disease more frequently have detectable anti-Ro/SSA and anti-La/SSB antibodies. [8]

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