What is the role of surgery in the treatment of multiple endocrine neoplasia type 1 (MEN1)?

Updated: Sep 14, 2018
  • Author: Thomas N Darling, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Patients may desire to have these cutaneous tumors removed because of cosmetic concerns, particularly with the larger facial angiofibromas. A variety of surgical methods have been used to treat angiofibromas in patients with tuberous sclerosis, and these treatments are likely applicable to angiofibromas in patients with multiple endocrine neoplasia type 1 (MEN1). These methods include the following [29, 30] :

  • Shave excision
  • Dermabrasion
  • Carbon dioxide laser
  • Combined pulsed dye laser and fractional resurfacing

Cosmetic improvement of facial angiofibromas in patients with MEN1 has been obtained with shave excision. In some cases, however, lesions treated in this way have slowly reappeared.

Collagenomas and lipomas can be excised, and lipomas can also be treated by liposuction.

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