Which patient groups have the highest prevalence of multiple endocrine neoplasia type 1 (MEN1)?

Updated: Nov 03, 2020
  • Author: Thomas N Darling, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Race- and sex-related demographics

No racial predilection is known for MEN1. Incidence rates of MEN1 are equal for men and women, and the frequencies of most tumors are similar in men and women, except that bronchial carcinoids are more common in women and thymic carcinoids are more common in men. [1, 16, 17]

Age

The age of onset of endocrine tumors is usually in the teenage years. However, symptoms from these tumors may not appear for several years, and the diagnosis is frequently delayed until the fourth decade of life. Cutaneous tumors may develop prior to the manifestation of overt clinical symptoms resulting from endocrine tumors. The earliest cutaneous tumors appear in the teenaged years. The recognition of these cutaneous tumors has been used in the presymptomatic diagnosis of patients with MEN1. [18, 19]


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