What is the prognosis of cutaneous candidiasis?

Updated: Jan 17, 2020
  • Author: Richard Harold "Hal" Flowers, IV, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Superficial candidal infections cause significant morbidity in older adults but are well treated with topical or oral therapy. Identification and cessation of triggers or aggravating factors is critical to prevent recurrence.

Systemic congenital candidiasis carries a grave prognosis and can lead to respiratory distress, meningitis, sepsis, or death. [31] Although the prognosis for congenital cutaneous candidiasis is generally good, untreated disease may carry a mortality rate of 8-40%. [27, 32]

Chronic mucocutaneous candidiasis (CMC) as an isolated cutaneous disease with a good prognosis. However, it is not curable and remains a chronic condition. It is often found in conjunction with endocrine and autoimmune disorders and, in some cases, may progress to an invasive infection; in both of these cases, there is high morbidity. [33] Furthermore, fatal conditions such as oral or esophageal squamous cell carcinoma and cerebral aneurysm, although rare, can be associated with CMC. [23, 34]

In patients with chronic granulomatous disease (CGD), those with Candida infection of the soft tissue or bone overall have a good prognosis. [35] However, if the infection becomes disseminated, significant morbidity may be observed. [35]


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