Which medications in the drug class Antifungal agents are used in the treatment of Intertrigo?

Updated: Aug 14, 2019
  • Author: Paras Vakharia, PharmD; Chief Editor: William D James, MD  more...
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Answer

Antifungal agents

Antifungal agents exert fungicidal effects by altering the permeability of fungal cell membrane. Their mechanism of action may also involve an alteration of RNA and DNA metabolism or an intracellular accumulation of peroxide toxic to fungal cells.

Carbol-Fuchsin (Castellani Paint)

Carbol-fuchsin is a first aid antiseptic and drying agent. The active ingredient is phenol 1.5%. Inactive ingredients are water, SD alcohol 40B (13%), resorcinol, acetone, and basic fuchsin.

Miconazole (Micatin, Monistat-Derm, Monistat) cream

Miconazole damages the fungal cell wall membrane by inhibiting biosynthesis of ergosterol. Membrane permeability is increased, causing nutrients to leak out, resulting in fungal cell death. Lotion is preferred in intertriginous areas. If cream is used, apply sparingly to avoid maceration effects.

Clotrimazole (Lotrimin, Mycelex, Gyne-Lotrimin)

Clotrimazole is a broad-spectrum antifungal agent that inhibits yeast growth by altering cell membrane permeability, causing death of fungal cells.


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