Which medications in the drug class Retinoid-like Agents are used in the treatment of Lymphedema?

Updated: Mar 24, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Retinoid-like Agents

These agents are thought to help normalize keratinization and decrease inflammatory and fibrotic changes.

Acitretin (Soriatane)

Acitretin, a metabolite of etretinate, is related to retinoic acid and retinol (vitamin A). Its mechanism of action is unknown; however, the drug is thought to exert its therapeutic effect by modulating keratinocyte differentiation, keratinocyte hyperproliferation, and tissue infiltration by inflammatory cells.

Tazarotene, topical (Tazorac)

Topical tazarotene (topical gel 0.1%) is a retinoid prodrug with an active metabolite that modulates the differentiation and proliferation of epithelial tissue. It may also have anti-inflammatory and immunomodulatory properties. Ensure that the skin is dry before the gel is applied.

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