Which medications in the drug class Anthelmintics are used in the treatment of Lymphedema?

Updated: Mar 24, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Filaria can cause lymphedema by obstruction.

Albendazole (Albenza)

Albendazole is a benzimidazole carbamate drug that inhibits tubulin polymerization, resulting in degeneration of cytoplasmic microtubules. It is converted in the liver to its primary metabolite, albendazole sulfoxide. Less than 1% of the primary metabolite is excreted in urine.

The plasma level is noted to rise significantly (as much as 5-fold) when albendazole is ingested after a high-fat meal. Experience with patients under age 6 years is limited.

To avoid an inflammatory response in the central nervous system (CNS), patients must also be started on anticonvulsants and high-dose glucocorticoids.

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