Which medications in the drug class Antibiotics are used in the treatment of Lymphedema?

Updated: Mar 24, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of this clinical setting.


Cefazolin is a first-generation, semisynthetic cephalosporin that arrests bacterial cell wall synthesis, inhibiting bacterial growth. It is primarily active against skin flora, including Staphylococcus aureus. This agent is typically used alone for skin and skin-structure coverage. The intravenous and intramuscular dosing regimens are similar.

Clindamycin (Cleocin)

Clindamycin is a lincosamide used for the treatment of serious skin and soft tissue staphylococcal infections. It is also effective against aerobic and anaerobic streptococci (but not enterococci). Clindamycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl transfer ribonucleic acid (t-RNA) from ribosomes, causing RNA-dependent protein synthesis to arrest.

Penicillin G benzathine (Bicillin L-A)

This agent interferes with the synthesis of cell wall mucopeptides during active multiplication, resulting in bactericidal activity. It is used to treat syphilis and for prophylaxis against recurrent streptococcal infections.

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