Which conditions are associated with secondary lymphedema?

Updated: Mar 24, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Answer

Recurrent episodes of cellulitis or streptococcal lymphangitis have also been linked to the development of lymphedema.

Rarely, herpes simplex infection can cause lymphangitis and resultant lymphedema. In one reported case, a patient with herpetic whitlow presented with acquired lymphedema of the hand. [31]

The peptide adrenomedullin (AM) is encoded by the ADM gene. One report sought to determine if a deficiency in AM predisposes to secondary lymphedema. [32] Endogenous AM was determined to play an important role in secondary lymphedema pathogenesis.

Another interesting report [33] notes a 75-year-old woman with a monoclonal gammopathy of uncertain significance (MGUS) and rapidly progressive lipolymphedema. The researchers speculated that MGUS and lymphedema might be due to initial fibrogenesis worsening preexisting lipedema.


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