Which diseases are associated with thrombophlebitis?

Updated: Aug 31, 2020
  • Author: Padma Chitnavis, MD; Chief Editor: Dirk M Elston, MD  more...
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Other disease states are associated with venous thromboembolism. Paroxysmal nocturnal hemoglobinuria, nephritic syndrome, and inflammatory bowel disease all are associated with increased risks of thromboembolism. [4] Alteration of the activity of matrix metalloproteinases influences mechanical properties of the vein wall. [79] The rate of peripheral venous thrombophlebitis following intravenous cannulation varies from 10-90%. [80] Newer catheter materials may be less thrombogenic. [81] Thrombophlebitis may also be a complication of medications that interfere with the coagulation pathway, anticoagulant treatment, [82] or infections. [83] Venous function has been suggested to be influenced by genetic factors. [84]

Mondor disease involves thrombophlebitis of the superficial veins of the breast and anterior chest wall. It has been associated with breast or axillary surgery, malignancy, and intense thoracoabdominal exercise training. [85, 86]

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