What is the role of tamoxifen in the pathophysiology of thrombophlebitis?

Updated: Aug 31, 2020
  • Author: Padma Chitnavis, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Unusual and poorly understood complications of tamoxifen use are thrombophlebitis and DVT. These complications occur in as many as 1% of treated patients. [55, 56] Results from the evaluation of various coagulation parameters and factors, including the sex hormone–binding globulin level, antithrombin activity, fibrinogen level, platelet count, protein C level, and fibrinopeptide A level, are all normal. [56, 57, 58, 59, 60] By contrast, one small case series of women experiencing venous thrombosis found APC resistance attributable to factor V Leiden heterozygous mutations in all 3 patients. [61]


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