What is the role of hypercoagulable states in the pathophysiology of thrombophlebitis?

Updated: Aug 31, 2020
  • Author: Padma Chitnavis, MD; Chief Editor: Dirk M Elston, MD  more...
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A number of primary and secondary hypercoagulable states can be assessed by obtaining an appropriate patient history and review of systems. Prior to 1993, only 3 inherited hypercoagulable factors had been recognized: antithrombin III, protein C, and protein S. Currently, 60-70% of patients with thrombosis can be identified as having a specific inherited thrombophilia. [2] Inherited hypercoagulable states are divided by experts into 5 main categories: (1) qualitative or quantitative defects of coagulation factor inhibitors, (2) increased level or function of coagulation factors, (3) hyperhomocysteinemia, (4) defects of the fibrinolytic system, and (5) altered platelet function.

The specific inherited thrombophilias are listed below. [3] The majority of these inherited diseases have identified gene mutations, some of which are used in diagnosis. Protein C deficiency alone has more than 160 genetic mutations associated with disease-causing states. [4]

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