Which medications in the drug class Sclerosing Agent are used in the treatment of Varicose Veins and Spider Veins?

Updated: Sep 25, 2020
  • Author: Robert Weiss, MD; Chief Editor: William D James, MD  more...
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Sclerosing Agent

These drugs are injected into varicose veins to produce endothelial destruction resulting in formation of a fibrotic cord. Eventually all the vascular tissue layers are reabsorbed.

Polidocanol (Asclera)

Polidocanol is a sclerosing agent indicated for uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1-3 mm in diameter) in lower extremities.

When injected intravenously, it induces endothelial damage, causing platelet aggregation at the site of damage. This results in vessel occlusion that is eventually replaced with connective fibrous tissue.

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