What factors predict the severity of venous insufficiency?

Updated: Oct 22, 2018
  • Author: Robert Weiss, MD; Chief Editor: William D James, MD  more...
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Experimental evidence shows that if the peak retrograde flows in the GSV, SSV, and popliteal vein add up to less than 10 mL/s, progressive visible stasis dermatitis and ulceration do not occur. If they add up to more than 15 mL/s, the incidence of ulceration is high. In some cases, purely superficial local reflux with a pressure of more than 7 mL/s can cause local ulceration.

In the San Diego Population Study, levels of circulating P-selectin were found to be correlated with the severity of CVI, though not with the incidence of CVI in general. [3] The study findings suggest that the pathogenesis of CVI may include activation of platelets and endothelial cells.

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