What is the role of high venous pressures in the pathogenesis of venous insufficiency?

Updated: Sep 25, 2020
  • Author: Robert Weiss, MD; Chief Editor: William D James, MD  more...
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High venous pressure is directly responsible for many aspects of venous insufficiency syndrome. Under normal conditions, two major mechanisms in the body operate to prevent venous hypertension. First, bicuspid valves in the veins prevent backflow and venous pooling. Deep venous thrombosis (DVT) commonly occurs at these valves, causing irreversible damage to the valve.

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