Which medications in the drug class Antihistamines are used in the treatment of Urticarial Vasculitis?

Updated: Sep 16, 2020
  • Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD  more...
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Antihistamines may serve as an adjunctive agent to relieve the itching or burning associated with urticarial vasculitis. Given alone, they usually provide only symptomatic relief.

Hydroxyzine (Atarax, Vistaril)

Hydroxyzine antagonizes H1 receptors in the periphery. It may suppress histamine activity in the subcortical region of the CNS. Hydroxyzine can be used for symptomatic control. The recommended antihistamine for pregnant patients is diphenhydramine. Hydroxyzine has been used safely in children.

Diphenhydramine (Benadryl, Benylin, Diphen, AllerMax)

Diphenhydramine is used for symptomatic relief of symptoms caused by release of histamine in hypersensitivity reactions. In pregnancy, use 25-50 mg PO q6h prn.

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