Which medications in the drug class Sulfone antibiotics are used in the treatment of Urticarial Vasculitis?

Updated: Jun 07, 2018
  • Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Sulfone antibiotics

Sulfone antibiotics are used for infectious diseases (eg, leprosy); however, sulfones are effective in inflammatory diseases. The mechanism of action may involve inhibiting free radical formation by neutrophils. In most case reports, these medications are effective only in purely cutaneous forms of urticarial vasculitis.

Dapsone (Avlosulfon)

Dapsone is the preferred sulfone. Other sulfones must be metabolized to dapsone for their effect. The mechanism of action is similar to that of sulfonamides in which competitive antagonists of PABA prevent the formation of folic acid, inhibiting bacterial growth.

Dosing guidelines for dermatologic use have been well described in dermatitis herpetiformis. Most case reports about effects in urticarial vasculitis use dermatitis herpetiformis dosing guidelines. Dapsone has been used extensively in chronic bullous diseases of childhood.


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