Which medications in the drug class Antimalarials are used in the treatment of Urticarial Vasculitis?

Updated: Jun 07, 2018
  • Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Antimalarials

Like other medications used to treat urticarial vasculitis, antimalarials are believed to exert their effect by their anti-inflammatory properties. Antimalarials reduce neutrophilic chemotaxis. In addition, they increase pH in lysosomes, which may affect antigen presentation. This class of medications usually is effective only in cutaneous disease.

Hydroxychloroquine (Plaquenil)

Hydroxychloroquine is the preferred antimalarial agent because of its low toxicity and high effectiveness profile. It is usually well tolerated if carefully monitored by the prescribing physician. Therapy is required for 4-8 weeks before evaluating effectiveness.


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