How is urticarial vasculitis categorized?

Updated: Jun 07, 2018
  • Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Urticarial vasculitis is divided into hypocomplementemic and normocomplementemic categories. [18]

Hypocomplementemia often is associated with a systemic condition, such as SLE (in which >50% of patients have hypocomplementemia). [3] In addition, as many as 71% of patients with hypocomplementemic urticarial vasculitis have a positive antinuclear antibody titer but do not fulfill the American Rheumatism Association criteria for SLE. [8] Some authors have suggested evaluation of hypocomplementemic urticarial vasculitis for immunoglobulin G antibodies to C1q. Individuals with these antibodies have a higher incidence of angioedema, ocular inflammation, glomerulonephritis, and obstructive pulmonary disease.

Normocomplementemic vasculitis can be associated with connective-tissue disease but at a much lower rate.


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