Which medications in the drug class Antibiotics, Other are used in the treatment of Stasis Dermatitis?

Updated: Mar 27, 2020
  • Author: Scott L Flugman, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Antibiotics, Other

These are used to treat open excoriations and erosions. Obvious superficial impetiginization should be treated with topical mupirocin or a systemic antibiotic with activity against Staphylococcus and Streptococcus species (eg, dicloxacillin, cephalexin, cefadroxil, levofloxacin).

Bacitracin (Baci-IM, Baciguent)

Bacitracin prevents the transfer of mucopeptides into the growing cell wall, which causes inhibition of bacterial cell wall synthesis.

Bacitracin and polymyxin B (Polysporin, Polycin, AK-Poly-Bac)

Bacitracin prevents transfer of mucopeptides into the growing cell wall, which causes inhibition of bacterial cell wall synthesis. Polymyxin B damages the bacterial cytoplasmic membrane and alters permeability, causing intracellular constituents to leak. This agent is used to treat open excoriations and erosions.

Mupirocin (Bactroban, Centany)

Mupirocin inhibits bacterial protein synthesis by binding to isoleucyl transfer-RNA synthetase.

Dicloxacillin

Dicloxacillin is used in the treatment of infections caused by penicillinase-producing staphylococci. It may be used as initial therapy when staphylococcal infection is suspected.

Cephalexin (Keflex)

Cephalexin is a first-generation cephalosporin that arrests bacterial growth by inhibiting bacterial cell wall synthesis. It has bactericidal activity against rapidly growing organisms. It has primary activity against skin flora and is used for skin infections or prophylaxis in minor procedures.

Levofloxacin (Levaquin)

Levofloxacin inhibits DNA gyrase and topoisomerase IV, resulting in bactericidal activity. It is used as an alternative agent for MRSA infection.

Cefadroxil

Cefadroxil is a first-generation semisynthetic cephalosporin that arrests bacterial growth by inhibiting bacterial cell wall synthesis. It has bactericidal activity against rapidly growing organisms, including S aureus, S pneumoniae, S pyogenes, Moraxella catarrhalis, E coli, Klebsiella species, and Proteus mirabilis.


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