Which systemic therapies are used in the treatment of stasis dermatitis?

Updated: Mar 27, 2020
  • Author: Scott L Flugman, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Based on theories regarding the pathogenesis of cutaneous inflammation in venous insufficiency, systemic therapies that have been hypothesized to have beneficial modulating effects on neutrophil function have been investigated.

Treatments that have been studied for venous ulcers, such as prostaglandin-E1 (PGE1) and pentoxifylline therapies, have been hypothesized to decrease cytokine-mediated neutrophil activation, leading to reduced inflammation. [42] However, even if these systemic therapies are proven to be unequivocally effective, it is unlikely that their use will extend beyond the scope of treatment of recalcitrant venous ulcers.


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