Which combination therapies are effective in the treatment of stasis dermatitis?

Updated: Mar 27, 2020
  • Author: Scott L Flugman, MD; Chief Editor: Dirk M Elston, MD  more...
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A single-arm, interventional pilot study by Maroo et all indicated that combination therapy with topical tacrolimus and oral doxycycline may be effective against stasis dermatitis. The study evaluated treatment results in 15 patients with stasis dermatitis resulting from chronic venous insufficiency in the lower limbs. The patients were treated for 4 weeks with topical tacrolimus 0.1% and oral doxycycline 100 mg. [41]

The investigators found that 86.6% of the patients demonstrated improvement of the dermatitis area, while 6.7% showed no improvement, and another 6.7% experienced worsened dermatitis. Two patients showed adverse effects.

The researchers also found that patients had significant improvement in pain, edema, erythema, pigmentation, and exudation, as well as a statistically significant reduction in ulcer size.

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