Which conditions should be included in the differential diagnoses of pyogenic granuloma (lobular capillary hemangioma)?

Updated: Feb 21, 2020
  • Author: Joseph C Pierson, MD; Chief Editor: William D James, MD  more...
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Also consider the following:

  • Angioendothelioma
  • Angiosarcoma
  • Granulation tissue
  • Hemangioendothelioma
  • Intravascular papillary endothelial hyperplasia (Masson tumor)
  • Spitz nevus [53]
  • Tufted hemangioma
  • Foreign body
  • Neurofibroma
  • Cutaneous endometriosis
  • Eccrine poroma
  • Orocutaneous fistula of odontogenic origin

Melanoma in childhood presents differently than the far more common adult variety, prompting a call for heightened vigilance with an additional A,B,C,D detection acronym in the pediatric population (Amelanotic; Bleeding; Bump; Color uniformity; De Novo, any Diameter) to be used together with conventional criteria. [54] Because they are frequently reddish papules that resemble pyogenic granulomas, it is crucial to keep that diagnostic possibility in mind.

Submit all removed specimens for histologic confirmation of the diagnosis. This is especially critical for persistent lesions. [55] Explore for a missed foreign body in the presence of a recurrent, intractable pyogenic granuloma. [17]

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