What causes pyogenic granuloma (lobular capillary hemangioma)?

Updated: Feb 21, 2020
  • Author: Joseph C Pierson, MD; Chief Editor: William D James, MD  more...
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The cause of the typical pyogenic granuloma (lobular capillary hemangioma) is not known. Trauma, hormonal influences, viruses, [10, 11] underlying microscopic arteriovenous malformations, production of angiogenic factors, and cytogenetic clonal deletion abnormalities [12] have all been implicated. While trauma was long considered a primary cause, one large study found only 7% of patients had a history of preceding trauma. [13]

Development of the lesions with the use of certain medications (retinoids, antiretrovirals, oncologic agents, and others) has been well documented (see History for a complete list).

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