How is Kaposi sarcoma (KS) prevented?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Reducing the HHV-8 infection rate prevents Kaposi sarcoma development.

Suggestions have been made that some antiherpetic agents, particularly foscarnet, may lower the HHV-8 infection rate.

Screening transplant recipients for HHV-8 infection may be beneficial. [72, 73, 74, 75, 76] Testing donors and recipients for HHV-8 is difficult, as there are no validated commercial serology kits available; however, limited HHV-8 antibody testing is available through some US reference laboratories and the US Centers for Disease Control and Prevention. [77] Many US donors originate from groups at high risk of HHV-8 transmission to recipients.

Use of the highly active anti-HIV therapy (ie, HAART) appears to significantly reduce the risk of developing new Kaposi sarcoma. [30]

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