What is the AIDS Clinical Trials Group classification for Kaposi sarcoma (KS)?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Stage the patient's disease and note any extracutaneous involvement. Staging this multicentric disorder has been a challenge. [64]

The AIDS Clinical Trials Group classification by Krown et al [65] in 1989 uses the following 3 categories, although the tumor/immune/system/systemic (TIS) illness grading method has limitations:

  • Tumor (T) - Good or bad risk signs (good when Kaposi sarcoma is confined to skin and/or lymph nodes and/or demonstrates minimal oral disease)

  • Immune system (I) - CD4 cell levels equal to or greater than 150/µL (good risk) versus less than 150/µL (poor risk)

  • Systemic illness (S) - Good or poor risk

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