What are the sexual predilections of Kaposi sarcoma (KS)?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Classic Kaposi sarcoma has an overwhelming male predominance, with a male-to-female ratio of approximately 10-15:1.

For endemic Kaposi sarcoma in Central Africa, the male-to-female ratio is near unity in childhood Kaposi sarcoma cases but often rises in puberty to 15:1.

In Corsica and Sardinia (where classic Kaposi sarcoma is endemic), with the arrival of AIDS, the ratio of male-to-female cases has dropped from 10:1 to 3:1. Children of women who are HIV-1 seropositive without Kaposi sarcoma have an aggressive form of childhood HIV-associated Kaposi sarcoma. A male-to-female ratio of 1.5:1 was observed.

A male-to-female ratio of 1.5:1 also was evident among renal transplant recipients in Arabia. [31]

In Zambia, Kaposi sarcoma represents up to 25% of childhood cancers and has an average male-to-female ratio of 1.76:1, with male predominance higher in children older than 5 years (2.5:1) than in children younger than 5 years (1.4:1).

Clinical manifestations and therapeutic response in men and women with AIDS-associated KS in Uganda differed between men and women. [32] At presentation, the median CD4 T-cell count was significantly lower in women than men, with women more likely than men to initially develop Kaposi sarcoma of the face and hard palate and more likely to develop lesions on the lower extremity. In addition, women were less likely than men to demonstrate clinical improvement.


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