What is the dosing protocol for propranolol in the treatment of infantile hemangioma?

Updated: Feb 06, 2019
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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Answer

Initial dosing is as follows:

  • Inpatient: Suggested for infants younger than 8 weeks of gestationally corrected age or with co-morbidconditions, starting dose at 1 mg/kg/day or 0.33 mg/kg/dose q8hr and check heart rate and blood pressure 1 and 2 hours after first 1-3 doses; if tolerated, increase to 2 mg/kg/day or 0.66 mg/kg/dose q8hr and if tolerated discharge to home on this regimen
  • Outpatient: Suggested for infants older than 8 weeks of gestationally corrected age and adequate social support, starting dose at 1 mg/kg/day or 0.33 mg/kg/dose q8hr and check heart rate and blood pressure 1 and 2 hours after first dose; if tolerated, patient is sent home and continues this dose for 3-7 days then returns and increases to 0.5 mg/kg/dose q8hr (1.5 mg/kg/day) and if tolerated is discharged to home on that dose; again, if tolerated for 3-7 days, then increase dose to 0.66 mg/kg q8hr (2 mg/kg/day)

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