How is propranolol used in PHACE syndrome associated with infantile hemangioma?

Updated: Nov 09, 2020
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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An expert panel has developed provisional recommendations for the use of propranolol, including in patients with PHACE syndrome (posterior fossa abnormalities, hemangioma, arterial lesions, cardiac abnormalities/aortic coarctation, and eye abnormalities). [10, 11] PHACE syndrome is associated with a higher risk of neurologic and cognitive impairment.

The provisional recommendations cover the following [10, 11] :

  • When to treat complicated infantile hemangiomas

  • Contraindications and pretreatment evaluation protocols

  • Formulation, target dose, and frequency of dosing

  • Initiation in infants

  • Cardiovascular monitoring

  • Ongoing monitoring

  • Prevention of hypoglycemia

The individual therapies are discussed in detail under Medication.

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