Which lab studies are indicated in the workup of infantile hemangiomas?

Updated: Feb 06, 2019
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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Answer

No laboratory studies have been universally accepted for the diagnosis and treatment of infantile hemangiomas; however, reports in the literature have investigated the use of serum vascular endothelial growth factor (VEGF) as well as urinary beta-fibroblast growth factor, VEGF, and matrix metalloproteinases (MMPs) as markers of hemangioma proliferation and differentiation. [5, 6]

Use of glucose transporter 1 (GLUT-1) stain is helpful for evaluating tissue removed during biopsy or excision. [60] Both proliferating and involuting infantile hemangiomas uniformly stain positively for GLUT-1, while other cutaneous vascular neoplasms, malformations, and normal cutaneous vasculature do not, making this stain very sensitive and specific for histologic confirmation of infantile hemangiomas. In addition, red blood cell membranes stain positively for GLUT-1, creating an effective internal control.


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