What is the relationship between infantile hemangiomas and hypothyroidism?

Updated: Feb 06, 2019
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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Answer

Rarely, infantile hemangiomas have been implicated in cases of consumptive hypothyroidism. [57] This was initially reported with hepatic hemangiomas; however, this has also been reported with bulky cutaneous infantile hemangiomas. [58] This phenomenon appears be secondary to high activity of the type 3 iodothyronine deiodinase enzyme in hemangioma tissue, which is responsible for degradation of T4 to reverse T3 (rT3). One case reported also demonstrated increased production of a thyrotropinlike hormone from a hepatic hemangioma. [59] Thyroid function tests should be ordered in the appropriate clinical setting.


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