What is Kasabach-Merritt phenomenon (KMP) in infantile hemangioma?

Updated: Feb 06, 2019
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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Answer

Kasabach-Merritt phenomenon (KMP) is marked by platelet sequestration and severe thrombocytopenia associated with a rapidly proliferating vascular neoplasm. This can be accompanied by a potentially fatal, generalized bleeding disorder. KMP is heralded by rapid enlargement, edema of the surrounding tissues, and accompanying purpura. [55]  Most cases of KMP are associated with kaposiform hemangioendothelioma or tufted angioma and not infantile hemangiomas, as previously believed. [35] The early reports of KMP were described in lesions in which a clinical, not histological, diagnosis was made. Vincristine and radiotherapy have been effective in several cases of KMP caused by kaposiform hemangioendotheliomas and tufted angiomas.


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