What is diffuse neonatal hemangiomatosis?

Updated: Nov 09, 2020
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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Diffuse neonatal hemangiomatosis is a potentially life-threatening condition characterized by numerous cutaneous hemangiomas accompanied by visceral hemangiomas. When more than five cutaneous hemangiomas are present, the risk of visceral lesions rises. The liver and gastrointestinal tract are affected most often, although any organ can be involved. Congestive heart failure is a cause of early mortality because of increased vascular volume. Evaluation should include an imaging study of the liver (eg, ultrasonography, MRI) and stool guaiac tests to rule out intestinal bleeding from gut hemangiomas if there is clinical concern. Oral propranolol is effective for hastening regression of hepatic hemangiomas. Systemic corticosteroids, interferon alfa, and conventional surgery are alternative treatments if propranolol is ineffective or contraindicated.

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