What is the clinical course of infantile hemangioma?

Updated: Nov 09, 2020
  • Author: Richard J Antaya, MD; Chief Editor: William D James, MD  more...
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Infantile hemangiomas characteristically exhibit early rapid growth followed by slow involution, as follows [1, 2, 3, 4] :

  • Rapid growth during the neonatal period (birth to 4 wk) is the historical hallmark of infantile hemangiomas

  • The hemangioma becomes elevated and dome shaped, lobulated, plaquelike, tumoral, or any combination of these morphologies

  • The most growth occurs during the first 4-6 months of life

  • Proliferation slows considerably between 6-12 months of life

  • Complete involution in 50% of infantile hemangiomas by age 5 years and 70% by age 7 years

  • Complete involution may take an additional 3-5 years in the remainder

See Clinical Presentation for more detail.

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