Which medications in the drug class Anti-inflammatory agents are used in the treatment of Erythema Nodosum?

Updated: May 11, 2020
  • Author: Jeanette L Hebel, MD; Chief Editor: William D James, MD  more...
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Anti-inflammatory agents

Anti-inflammatory agents provide symptomatic relief for lesional tenderness, arthralgia, and fever.

Aspirin (Anacin, Ascriptin, Bayer Aspirin)

Aspirin is a salicylate used for anti-inflammatory, analgesic, and antipyretic properties. It treats mild-to-moderate pain and headache. Aspirin inhibits prostaglandin synthesis, which prevents the formation of platelet-aggregating thromboxane A2. It acts on the heat-regulating center of the hypothalamus, and it vasodilates peripheral vessels to reduce fever. Enteric-coated and extended-release tablets are available.

Naproxen (Naprelan, Naprosyn, Aleve, Anaprox)

Naproxen has analgesic, anti-inflammatory, and antipyretic properties. It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which is responsible for prostaglandin synthesis.

Indomethacin (Indocin, Indochron E-R)

Indomethacin is rapidly absorbed; metabolism occurs in the liver by demethylation, deacetylation, and glucuronide conjugation; it inhibits prostaglandin synthesis.


Colchicine reduces the formation of uric acid crystals in affected joints, thereby reducing the amount of acute inflammation and pain; it also decreases uric acid levels in the blood.

Colchicine can be used in combination with probenecid on a long-term basis to prevent gout or it can be used alone to treat the pain and inflammation of acute gout attacks. Discontinue usage when the pain of a gout attack begins to subside, when the maximum dose is reached, or when GI tract symptoms (eg, nausea, vomiting, diarrhea) indicate cellular poisoning.

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