Which lab studies are performed in the diagnosis of erythema nodosum (EN)?

Updated: May 11, 2020
  • Author: Jeanette L Hebel, MD; Chief Editor: William D James, MD  more...
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Perform throat culture as part of the initial workup to exclude group A beta-hemolytic streptococcal infection.

Perform erythrocyte sedimentation rates often as part of the initial workup. The rate often is very high.

Antistreptolysin titer is elevated in some patients with streptococcal disease, but normal values do not exclude streptococcal infection. Evaluate titer levels during the initial workup, since streptococcal disease is a common cause of erythema nodosum.

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