What is the role of sarcoidosis in erythema nodosum (EN)?

Updated: May 11, 2020
  • Author: Jeanette L Hebel, MD; Chief Editor: William D James, MD  more...
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Approximately 10-22% of all erythema nodosum cases are caused by sarcoidosis. [15]  The most common cutaneous manifestation of sarcoidosis is erythema nodosum. [16] A characteristic form of acute sarcoidosis involves the association of erythema nodosum, hilar lymphadenopathy, fever, arthritis, and uveitis, which has been termed Löfgren syndrome. This presentation has a good prognosis, with complete resolution within several months in most patients. HLA-DRB1*03 is associated with Löfgren syndrome. Most DRB1*03-positive patients have resolution of their symptoms within 2 years; however, nearly half of DRB1*03-negative patients have an unremitting course. [17]

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