What are the treatment options for recalcitrant oral lichen planus (OLP)?

Updated: Mar 29, 2018
  • Author: Jaisri R Thoppay, DDS, MBA, MS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Erosive oral lichen planus that is recalcitrant to topical corticosteroids may respond to topical tacrolimus. [46, 47] Other potential therapies for recalcitrant oral lichen planus include cyclosporin, [48] hydroxychloroquine, [49] azathioprine, [50] dexamethasone elixir, mycophenolate, [51] dapsone, [47] systemic corticosteroids, and topical and systemic retinoids. [48] Oral lichen planus has been treated successfully with thalidomide, [15, 16] but this is considered experimental and associated with significant potential adverse effects; only clinicians trained thoroughly by the manufacturer can prescribe this agent.

Close monitoring of patients is essential when these medications are prescribed. Only practitioners completely familiar with the use of immunosuppressive drugs should attempt such treatment.

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