What is the role of Candida albicans infection in the etiology of oral lichen planus (OLP)?

Updated: Sep 15, 2020
  • Author: Jaisri R Thoppay, DDS, MBA, MS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Some studies show an increased incidence of Candida albicans infection in oral lichen planus. A causal role for C albicans infection in oral lichen planus has not been identified.

Some studies have revealed a prevalence of viral infections in oral lichen planus (eg, hepatitis C virus [HCV]). Some studies report human papillomavirus (HPV) types 6, 11, 16, or 18. [25, 26] Dysplastic oral lichen planus lesions had a higher prevalence of HPV-16 compared with nondysplastic oral lichen planus lesions. Some study findings suggest an association between oral lichen planus and chronic hepatic diseases such as HCV infection, autoimmune chronic active hepatitis, and primary biliary cirrhosis. [27, 28] This association probably reflects the geographic distribution of HCV disease and lichenoid reactions to various drug therapies (eg, interferon-alfa for HCV disease, penicillamine for primary biliary cirrhosis). Oral lichen planus is associated with HCV infection and liver disease in parts of Japan and southern Europe. An association between oral lichen planus and HCV infection has not been detected in British, French, German, Scandinavian, or American patients.

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