What is the role of medications in the treatment of mucocele and ranula?

Updated: Oct 19, 2020
  • Author: Catherine M Flaitz, DDS, MS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Examples of treating multiple superficial mucoceles with clobetasol 0.05%, a high-potency topical steroid, or with gamma-linolenic acid (oil of evening primrose), which is a prostaglandin E precursor, have some degree of success in limited patients. [36, 37] However, the lesions recur within a few months when gamma-linolenic acid is discontinued, while periodic use of the topical steroids is used to control flare-ups.

Mucoceles and ranulas may spontaneously resolve, especially in infants and young children. In a retrospective study, approximately 44% of mucoceles in children spontaneously resolved after an average of 3 months. [14] If symptoms are minimal in this young age group, aspiration of the lesions and periodic follow-up for 6 months have been suggested as an alternative to surgery. [38] Although there is minimal evidence to support the use of intralesional steroids for the management of oral mucoceles, this treatment option may be an alternative when surgery cannot be performed. [39]

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