What is the prevalence of mucocele and ranula in the US?

Updated: Oct 19, 2020
  • Author: Catherine M Flaitz, DDS, MS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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In the Minnesota Oral Prevalence Study that included 23,616 white adults older than age 35 years, mucoceles represented the 17th most common oral mucosal lesion, with a prevalence of 2.4 cases per 1000 people. Data from the Third National Health and Nutrition Examination Survey (NHANES III) that included 17,235 adults aged 17 years or older documented an overall prevalence ranking of 44 for the mucocele and a point prevalence of 0.02%. In the same study, which consisted of 10,030 children aged 2-17 years, the mucocele had a point prevalence of 0.04%. Congenital mucoceles in newborns are rare, with sporadic case reports and small case series appearing in the literature [8, 9]

Mucoceles of the anterior lingual salivary glands (glands of Blandin and Nuhn) are relatively uncommon. In the Minnesota Oral Disease Prevalence Study, Blandin and Nuhn mucoceles had a lower prevalence than mucoceles at other locations, or 0.1 cases per 1000 persons. This type of mucocele represents an estimated 2-10% of all mucoceles.

Superficial mucoceles are typically located in the soft palate, the retromolar region, and the posterior buccal mucosa. They represent approximately 6% of all mucoceles. Multiple superficial mucoceles have been reported in a small number of patients.

In an 11-year retrospective review of oral mucoceles and sialocysts from a university-based oral and maxillofacial pathology laboratory, most lesions were found to be mucus retention phenomenon (mucoceles, 91%). In descending order, the other diagnoses included ranulas (6%), and mucus retention cysts (5%). Mucoceles outnumbered mucus retention cysts by a ratio of 15.3:1.0. More limited histopathologic studies document that the mucus retention cyst (those lesions with an epithelial lining) accounts for 3-18% of all oral mucoceles.

Ranulas have a prevalence of 0.2 cases per 1000 persons and are ranked 41st in the Minnesota Oral Disease Prevalence Study. As noted previously, ranulas accounted for 6% of all oral sialocysts in a university-based oral and maxillofacial biopsy service. The prevalence of cervical (plunging) ranulas is not known; however, these lesions are considered uncommon. The number of ranulas that represents a true retention cyst ranges from less than 1% to 10%.

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