What is the basis for treatment selection in aphthous stomatitis (canker sore)?

Updated: Sep 25, 2020
  • Author: Ginat W Mirowski, MD, DMD; Chief Editor: William D James, MD  more...
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Many therapeutic options, with varying degrees of supporting evidence, are recommended for the treatment of aphthous stomatitis. The choice should be guided by disease severity, level of evidence, cost, and adverse effect profile. Treatment for recurrent aphthous ulcers is directed at palliation of symptoms, shortening of healing time, [83, 84] and prophylaxis against future episodes.

Of note, many of the treatments are used without research demonstrating therapeutic results specific to aphthous stomatitis. A 2012 Cochrane review of systemic treatments for aphthous stomatitis found that data from four major trials lacked methodological rigor and concluded that no single therapy could be recommended given the data currently available. [85]

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