Which histologic findings are characteristic of cheilitis granulomatosa?

Updated: Jun 21, 2018
  • Author: Alan Snyder; Chief Editor: William D James, MD  more...
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Histologic changes are not always conspicuous or specific in many cases of long duration; the infiltrate becomes denser and pleomorphic, and small, focal, noncaseating, sarcoidal granulomas are formed that are indistinguishable from Crohn disease or sarcoidosis.

The inflammatory response is probably mediated by cytokines such as tumor necrosis factor-alpha and by protease-activated receptors (PARs), matrix metalloproteinases (MMPs), and cyclo-oxygenases (COXs). There is submucosal chronic inflammation with many Th1 and mononuclear, interleukin 1–producing cells; large, active, dendritic B cells; and noncaseating granulomas. [34] Small granulomas occur in the lymphatic walls in some cases. Similar changes may be present in cervical lymph nodes.

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