Which medications in the drug class Neuromuscular Blocking Agents are used in the treatment of Hyperhidrosis?

Updated: Mar 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Neuromuscular Blocking Agents

These agents inhibit the transmission of nerve impulses at the neuromuscular junction of skeletal muscle and/or autonomic ganglia.

OnabotulinumtoxinA (BOTOX®)

OnabotulinumtoxinA prevents calcium-dependent release of acetylcholine and produces a state of denervation at the neuromuscular junction and postganglionic sympathetic cholinergic nerves in the sweat glands.

Each injection produces an area of anhydrosis approximately 1.2 cm in diameter. Treatment reportedly results in anhydrosis lasting 4-12 monts.

Injections of botulinum toxin must be repeated at varying intervals to maintain long-term results.

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